KEM Hospital Research Centre, Pune

K.E.M Hospital, Pune celebrated its diamond jubilee in 1972. At that time a need was felt to further improve and expand their services.Read Further

Dept. of Medicine

Head of Department: Dr. Anand Godbole

The department was started in the early 1970's by Dr. V.R.Pai, and was assisted by Drs. F.F.Wadia and Dr. K.M. Gangwal. There were also inputs from Drs. B.B. Gokhale (dermatology), Dr. M.K.Kale (pulmonology) and Dr. S.C.Pant (psychiatry). In 1975, a 3-bedded ICU and a one dialysis machine Renal Unit was added. The department expanded by leaps and bounds in the early and late 80's with many more consultants joining in internal medicine, as well as many specialties like cardiology, nephrology, neurology, gastro-enterology, endocrinology, and intensive care.

Research Studies/Trials Undertaken

Title: Contribution of cystopathy to Chronic Kidney Disease(CKD) in diabetic patients
Principal Investigator: Dr.F.F.Wadia
Sponsor: Departmental Project
Period of Study: Jan 2004 to June 2006

(This Paper was presented at the West Zone Annual Conference, 2006, Indian Society of Nephrology)

Objective:To determine the clinical profile and contribution of diabetic cystopathy, a combination of urothelial, detrusor and automatic dysfunction to chronic kidney disease(CKD) in diabetes.

Methodology:All patients of diabetes mellitus with CKD, attending the nephrology clinic were evaluated for the duration, type and control of diabetes, hypertension and presence of concomitant macro and micro vascular disease. Confirmation of cystopathy was done by Urodynamic studies.

Results:29 patients(16 male, 13 female) were studied -2 with type 1 and 27 with type 2 diabetes. The duration of diabetes was 15.73 ± 9.1 years. 23 patients were hypertensive for 3.48 ± 3.24 years. The blood sugar control was poor with the HbA1C of 8.2 ± 1.31%. 18 patients had evidence of diabetic nephropathy with daily proteinuria of 1.95 ± 1.82 gm. Retinopathy was seen in 18. Macro vascular disease was seen in 13 and sensory or motor neuropathy in 20 patients. Urinary tract infection had been noted in 18 patients. 2 patients presented with signs of uremia and 5 had presentations unrelated to diabetic cystopathy.

Urodynamic studies revealed poor proprioception in 14 patients, detrusor dysfunction in 9 and a mixed picture in 8. The presenting serum creatinine was 4.31 ± 2.63 mg%, which improved significantly to 3.1 ± 2.27 mg% (p=0.00049) at discharge. Of the 4 patients who were dialysis dependent, 3 became dialysis independent.

Title: Formotel Monotherapy in subjects
Principal Investigator: Dr P.G. Khatavkar

A 26 weeks placebo controlled efficacy and safety of mometasone furoate/formotel fumarate combination formulation compared with mometasone furoate and formotel montherapy in subjects with persistent Asthma previously treated low dose inhaled